Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10318584 | 0.85 | USP2 (0.48) | ALDH1A1KDM4EADRB1USP2TSHR | |
| SCHEMBL22802008 | 0.85 | NPC1 (0.47) | NPC1RAB9AMAPTALDH1A1KMT2A | |
| SCHEMBL3770299 | 0.85 | NPC1 (0.47) | NPC1RAB9AMAPTALDH1A1KMT2A | |
| SCHEMBL3770301 | 0.85 | NPC1 (0.47) | NPC1RAB9AMAPTALDH1A1KMT2A | |
| SCHEMBL28510427 | 0.85 | ALDH1A1 (0.51) | NPC1RAB9AMAPTALDH1A1KMT2A | |
| SCHEMBL28919140 | 0.81 | HPGD (0.48) | RAB9AALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL28837016 | 0.78 | ADRB1 (0.56) | ALDH1A1KDM4ELMNAADRB1USP2 | |
| SCHEMBL6094124 | 0.76 | ALDH1A1 (0.65) | NPC1RAB9AMAPTALDH1A1KMT2A | |
| SCHEMBL232986 | 0.76 | ALDH1A1 (0.65) | NPC1RAB9AMAPTALDH1A1KMT2A | |
| SCHEMBL236047 | 0.76 | ADRB1 (0.52) | ALDH1A1KDM4ELMNAADRB1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050070539-A1 | Benzoyl-piperazine derivatives | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070539-A1 | Benzoyl-piperazine derivatives | OPRL1, ACHE, PNMT | NPC1 780/4885RAB9A 1415/4885MAPT 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.