Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | PTPRC | P08575 | 2/20 | 0.54 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.51 |
| ▸ | TUBB | P07437 | 1/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.51 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.51 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.51 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.51 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.51 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.51 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30673946 | 1.00 | MAOA (0.54) | MAOAPTPRCTUBB4ATUBBTUBA3C | |
| Benzocarbazoledione SCHEMBL22541347 | 0.92 | MAOA (0.54) | MAOAPTPRCTUBB4ATUBBTUBA3C | |
| SCHEMBL5866546 | 0.89 | MAOA (0.59) | MAOAPTPRCTUBB4ATUBBTUBA3C | |
| SCHEMBL4053013 | 0.84 | PTPRC (0.54) | MAOAPTPRCTUBB4ATUBBTUBA3C | |
| SCHEMBL30480799 | 0.84 | PTPRC (0.54) | MAOAPTPRCTUBB4ATUBBTUBA3C | |
| SCHEMBL21561768 | 0.83 | ALDH1A1 (0.56) | PTPRCTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29941542 | 0.82 | SERPINE1 (0.46) | MAOAPTPRCSMN1; SMN2LMNAKDM4E | |
| SCHEMBL2765272 | 0.82 | SERPINE1 (0.46) | MAOAPTPRCSMN1; SMN2LMNAKDM4E | |
| SCHEMBL7818524 | 0.81 | KDM4E (0.52) | MAOAPTPRCSMN1; SMN2LMNAKDM4E | |
| SCHEMBL13043812 | 0.81 | MAPK14 (0.52) | MAOAPTPRCSMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108503578-B | Synthetic method of indeno- [1,2-b ] indole-10 (5H) -ketone compound | 中国烟草总公司郑州烟草研究院 | 2020-07-24 | — | — | CN | claimed |
| US-6844445-B2 | Indenoindolone compounds | LES LABORATOIRES SERVIER (FR) | 2005-01-18 | — | — | US | claimed |
| EP-1245565-B1 | Indenoindolone derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | claimed |
| US-20020173531-A1 | Indenoindolone compounds | LES LABORATOIRES SERVIER (FR) | 2002-11-21 | — | — | US | claimed |
| EP-1245565-A1 | Indenoindolone derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2002-10-02 | — | — | EP | claimed |
| CN-108503578-B | Synthetic method of indeno- [1,2-b ] indole-10 (5H) -ketone compound | 中国烟草总公司郑州烟草研究院 | 2020-07-24 | — | — | CN | disclosed |
| CN-1185214-C | Novel indeno indolone compound, its preparation method and drug composition comprising the same | SERVIR LAB (FR) | 2005-01-19 | — | — | CN | disclosed |
| US-6844445-B2 | Indenoindolone compounds | LES LABORATOIRES SERVIER (FR) | 2005-01-18 | — | — | US | disclosed |
| US-6844445-B2 | Indenoindolone compounds | LES LABORATOIRES SERVIER (FR) | 2005-01-18 | — | — | US | disclosed |
| EP-1245565-B1 | Indenoindolone derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | disclosed |
| US-20020173531-A1 | Indenoindolone compounds | LES LABORATOIRES SERVIER (FR) | 2002-11-21 | — | — | US | disclosed |
| US-20020173531-A1 | Indenoindolone compounds | LES LABORATOIRES SERVIER (FR) | 2002-11-21 | — | — | US | disclosed |
| JP-2002322150-A | NEW INDENOINDOLONE COMPOUND, PRODUCTION METHOD THEREOF, AND MEDICAL COMPOSITION CONTAINING THE SAME | LAB SERVIER | 2002-11-08 | — | — | JP | disclosed |
| CN-1375490-A | Novel indeno indolone compound, its preparation method and drug composition comprising the same | SERVIR LAB (FR) | 2002-10-23 | — | — | CN | disclosed |
| EP-1245565-A1 | Indenoindolone derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2002-10-02 | — | — | EP | disclosed |
| EP-1245565-A1 | Indenoindolone derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2002-10-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020173531-A1 | Indenoindolone compounds | MTNR1A, MTNR1B, CYP11B1 | MAOA 535/4885PTPRC 4764/4885TUBB4A 3930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.