Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL651421 | 0.95 | AGTR1 (0.41) | AGTR1AGTR2MME | |
| SCHEMBL651207 | 0.86 | MEN1 (0.36) | MEN1KMT2AAGTR1AGTR2MME | |
| SCHEMBL647745 | 0.82 | AGTR1 (0.35) | AGTR1AGTR2 | |
| SCHEMBL651121 | 0.77 | MEN1 (0.34) | MEN1KMT2AAGTR1 | |
| SCHEMBL651422 | 0.76 | AGTR1 (0.42) | AGTR1AGTR2 | |
| SCHEMBL652197 | 0.75 | AGTR1 (0.35) | AGTR1AGTR2 | |
| SCHEMBL650385 | 0.72 | ADORA3 (0.36) | MEN1KMT2AAGTR1AGTR2 | |
| SCHEMBL649425 | 0.68 | KMT2A (0.37) | KMT2AAGTR1MME | |
| SCHEMBL650169 | 0.67 | MEN1 (0.37) | MEN1KMT2A | |
| SCHEMBL648737 | 0.67 | TSHR (0.37) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |