Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | CTSC | P53634 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL650170 | 0.80 | TRPA1 (0.37) | MEN1KMT2ATRPA1S1PR1 | |
| SCHEMBL14572949 | 0.76 | TRPA1 (0.38) | MEN1KMT2ATRPA1S1PR1 | |
| SCHEMBL651503 | 0.74 | GRIN2B (0.35) | MEN1KMT2ATRPA1S1PR1 | |
| SCHEMBL648229 | 0.72 | TRPA1 (0.39) | MEN1KMT2ATRPA1S1PR1 | |
| SCHEMBL650605 | 0.69 | TRPA1 (0.38) | MEN1KMT2ATRPA1S1PR1 | |
| SCHEMBL652764 | 0.68 | TRPA1 (0.38) | MEN1KMT2ATRPA1S1PR1 | |
| SCHEMBL651207 | 0.68 | MEN1 (0.36) | MEN1KMT2A | |
| SCHEMBL650395 | 0.67 | MEN1 (0.35) | MEN1KMT2A | |
| SCHEMBL650190 | 0.67 | ROCK2 (0.38) | TRPA1 | |
| SCHEMBL651421 | 0.67 | AGTR1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |