Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL144972 | 0.78 | TDP1 (0.52) | MAPTTDP1ALDH1A1GAAHPGD | |
| SCHEMBL347685 | 0.77 | TDP1 (0.50) | MAPTTDP1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL7561838 | 0.76 | MAPT (0.49) | MAPTTDP1ALDH1A1POLBGAA | |
| SCHEMBL26616888 | 0.76 | MAPT (0.49) | MAPTTDP1ALDH1A1POLBGAA | |
| Hydrochloric Acid SCHEMBL29730240 | 0.75 | TDP1 (0.48) | MAPTTDP1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL27928253 | 0.75 | TDP1 (0.48) | MAPTTDP1ALDH1A1GAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5962620 | 0.75 | TDP1 (0.48) | MAPTTDP1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL6049418 | 0.75 | ALDH1A1 (0.46) | MAPTTDP1ALDH1A1GAAHTT | |
| Ammonia Solution, Strong SCHEMBL27928251 | 0.75 | TDP1 (0.48) | MAPTTDP1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL632881 | 0.74 | MAPT (0.47) | MAPTTDP1ALDH1A1HPGDTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020156109-A1 | 1,4-dihydropyridine derivative with a guaiacoxypropanolamine and/or phenoxypropanolamine moiety | CHEN ING-JUN (TW) | 2002-10-24 | — | — | US | claimed |
| US-20050009886-A1 | 1,4-Dihydropyridine derivative with a guaiacoxypropanolamine and/or phenoxypropanolamine moiety | CHEN ING-JUN (TW) | 2005-01-13 | — | — | US | disclosed |
| US-6794399-B2 | BETA-ADRENORECEPTOR AND CALCIUM CHANNEL BLOCKING AGENT; INDUCED VASORELAXING EFFECT | CHEN ING-JUN (TW) | 2004-09-21 | — | — | US | disclosed |
| US-20020156109-A1 | 1,4-dihydropyridine derivative with a guaiacoxypropanolamine and/or phenoxypropanolamine moiety | CHEN ING-JUN (TW) | 2002-10-24 | — | — | US | disclosed |
| EP-1108710-A1 | GUAIACOXYPROPANOLAMINES WITH ALPHA/BETA-ADRENERGIC BLOCKING ACTIVITY | Cheng, Ing-Jun (TW) | 2001-06-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156109-A1 | 1,4-dihydropyridine derivative with a guaiacoxypropanolamine and/or phenoxypropanolamine moiety | ADRA1D, ADRA2C, ADRB3 | MAPT 3761/4885TDP1 2961/4885ALDH1A1 303/4885 |
| US-20050009886-A1 | 1,4-Dihydropyridine derivative with a guaiacoxypropanolamine and/or phenoxypropanolamine moiety | ADRB3, ADRB1, ADRA1D | MAPT 3000/4885TDP1 3173/4885ALDH1A1 707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.