Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.72 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.51 |
| ▸ | DRD2 | P14416 | 5/20 | 0.47 |
| ▸ | HTR2A | P28223 | 5/20 | 0.47 |
| ▸ | HTR2C | P28335 | 5/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6500406 | 0.99 | HTR7 (0.70) | HTR7OPRL1SIGMAR1DRD2HTR2A | |
| SCHEMBL6491393 | 0.84 | HTR7 (0.71) | HTR7OPRL1SIGMAR1DRD2HTR2A | |
| SCHEMBL6492092 | 0.84 | HTR7 (1.00) | HTR7OPRL1SIGMAR1DRD2HTR2A | |
| Hydrochloric Acid SCHEMBL6491157 | 0.83 | HTR7 (0.69) | HTR7OPRL1SIGMAR1DRD2HTR2A | |
| Hydrochloric Acid SCHEMBL6490630 | 0.83 | HTR7 (0.98) | HTR7OPRL1SIGMAR1DRD2HTR2A | |
| SCHEMBL6494213 | 0.78 | OPRL1 (0.58) | HTR7OPRL1SIGMAR1KCNH2 | |
| Hydrochloric Acid SCHEMBL6490983 | 0.77 | OPRL1 (0.57) | HTR7OPRL1SIGMAR1KCNH2 | |
| SCHEMBL6081319 | 0.74 | SIGMAR1 (0.73) | HTR7OPRL1SIGMAR1DRD2HTR2A | |
| SCHEMBL6492495 | 0.74 | SIGMAR1 (0.73) | HTR7OPRL1SIGMAR1DRD2HTR2A | |
| SCHEMBL6493040 | 0.74 | SIGMAR1 (0.73) | HTR7OPRL1SIGMAR1DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6969724-B2 | Compounds | SMITHKLINE BEECHAM-SPA (GB) | 2005-11-29 | — | — | US | claimed |
| US-20040024218-A1 | Novel compounds | SMITHKLINE BEECHAM SPA | 2004-02-05 | — | — | US | claimed |
| EP-1129072-A2 | N-SUBSTITUTED AZACYCLES, THEIR PREPARATION AND THEIR USE AS ORL-1 RECEPTOR LIGANDS | Smithkline Beecham S.p.A. (IT) | 2001-09-05 | — | — | EP | claimed |
| WO-2000027815-A2 | N-SUBSTITUTED AZACYCLES, THEIR PREPARATION AND THEIR USE AS ORL-1 RECEPTOR LIGANDS | SMITHKLINE BEECHAM SPA (IT) | 2000-05-18 | — | — | WO | claimed |
| US-6969724-B2 | Compounds | SMITHKLINE BEECHAM-SPA (GB) | 2005-11-29 | — | — | US | disclosed |
| US-6849619-B2 | Substituted pyridoindoles as serotonin agonists and antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-01 | — | — | US | disclosed |
| US-20040186094-A1 | Substituted pyridoindoles as serotonin agonists and antagonists | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-09-23 | — | — | US | disclosed |
| US-6699852-B2 | ANTISEROTONIN AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-03-02 | — | — | US | disclosed |
| US-20040024218-A1 | Novel compounds | SMITHKLINE BEECHAM SPA | 2004-02-05 | — | — | US | disclosed |
| US-20020173503-A1 | Substituted pyridoindoles as serotonin agonists and antagonists | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020173503-A1 | Substituted pyridoindoles as serotonin agonists and antagonists | HTR1A, HTR1B, HTR7 | HTR7 3/4885OPRL1 19/4885SIGMAR1 121/4885 |
| US-20040186094-A1 | Substituted pyridoindoles as serotonin agonists and antagonists | HTR1A, HTR1B, HTR7 | HTR7 3/4885OPRL1 19/4885SIGMAR1 121/4885 |
| US-20040024218-A1 | Novel compounds | OXER1, CLIC1, CCR1 | HTR7 1189/4885OPRL1 9/4885SIGMAR1 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.