Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL510440 | 0.81 | MAPT (0.50) | MAPK14MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL19612205 | 0.77 | MAPT (0.64) | MAPK14MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL7615166 | 0.77 | MEN1 (0.44) | MAPTHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11824469 | 0.76 | — | — | |
| SCHEMBL27564586 | 0.74 | ALDH1A1 (0.43) | MAPTMAPK1TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL5728945 | 0.74 | L3MBTL1 (0.37) | MAPTMAPK1L3MBTL1HPGDRAB9A | |
| SCHEMBL8365991 | 0.73 | KDM1A (0.44) | HTR1AHPGDNPC1SMN1; SMN2 | |
| SCHEMBL5934194 | 0.72 | MAPT (0.44) | MAPK14MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL1446254 | 0.72 | HPGD (0.46) | MAPK14MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL28239249 | 0.72 | MAPT (0.44) | MAPK14MAPTMAPK1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |
| US-6844347-B1 | Cyclic guanosine monophosphate modulators; cardiovascular diseases; guanylate cyclase activation | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-01-18 | — | — | US | disclosed |