Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.44 |
| ▸ | MGMT | P16455 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | PPIA | P62937 | 1/20 | 0.39 |
| ▸ | HPD | P32754 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8056262 | 0.83 | MGMT (0.44) | MEN1KMT2APIN1MGMTMAPT | |
| SCHEMBL15013285 | 0.79 | MAPT (0.55) | MEN1KMT2AMGMTMAPTCYP19A1 | |
| SCHEMBL15536327 | 0.78 | PIN1 (0.50) | MEN1KMT2APIN1MGMTMAPT | |
| SCHEMBL7615170 | 0.78 | PIN1 (0.44) | MEN1KMT2APIN1MGMTMAPT | |
| SCHEMBL6504472 | 0.77 | MAPK14 (0.48) | MAPTNPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL18396641 | 0.76 | PIN1 (0.51) | MEN1KMT2APIN1MGMTMAPT | |
| SCHEMBL7882348 | 0.75 | MAPT (0.49) | MEN1KMT2APIN1MGMTMAPT | |
| SCHEMBL16266200 | 0.74 | MGMT (0.51) | MEN1KMT2AMGMTMAPTCYP19A1 | |
| SCHEMBL9528862 | 0.74 | HTR1A (0.54) | MEN1KMT2APIN1MGMTMAPT | |
| SCHEMBL7686425 | 0.72 | MEN1 (0.47) | MEN1KMT2AMAPTCYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786459-B1 | Process for the preparation of a hetero-bicyclic alcohol enantiomer | DUPHAR INT RES (NL) | 2002-08-28 | — | — | EP | disclosed |
| US-5948909-A | BLOCKING; CYCLIZATION | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1999-09-07 | — | — | US | disclosed |
| EP-0786459-A1 | Process for the preparation of a hetero-bicyclic alcohol enantiomer | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1997-07-30 | — | — | EP | disclosed |