Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.36 |
| ▸ | RARA | P10276 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | RARG | P13631 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6495548 | 0.93 | TP53 (0.40) | MAPTACACBHPGDNPSR1MEN1 | |
| SCHEMBL7676306 | 0.91 | MAPT (0.42) | MAPTHPGDNPSR1MEN1KMT2A | |
| SCHEMBL6495786 | 0.87 | NPC1 (0.38) | NPSR1LMNATP53RARBPPARG | |
| SCHEMBL6495943 | 0.86 | FFAR1 (0.39) | MAPTACACBPPARGPPARASMN1; SMN2 | |
| SCHEMBL6505584 | 0.85 | DGAT1 (0.38) | MAPTACACBHPGDNPSR1MEN1 | |
| SCHEMBL6496054 | 0.84 | KDM4E (0.40) | MAPTACACBHPGDNPSR1MEN1 | |
| SCHEMBL6503799 | 0.82 | EGLN2 (0.35) | MAPTACACBTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL6502680 | 0.81 | CDC7 (0.41) | MAPTHPGDMEN1KMT2ALMNA | |
| SCHEMBL6497551 | 0.80 | P2RX3 (0.37) | ACACBMEN1KMT2APPARGPPARA | |
| SCHEMBL6503012 | 0.79 | MAPT (0.39) | MAPTACACBMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |