Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4664636 | 0.81 | FAAH (0.42) | FAAHGAAL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL6498349 | 0.79 | TSHR (0.60) | GAAHPGDNPSR1NPC1RAB9A | |
| SCHEMBL19151066 | 0.79 | CARM1 (0.49) | MAPK8MAPK1LMNASMN1; SMN2HPGD | |
| SCHEMBL3414085 | 0.78 | KDM1A (0.51) | GAAMAPK8MAPK1LMNAKDM1A | |
| SCHEMBL30420959 | 0.78 | KDM1A (0.48) | MAPK8MAPK1L3MBTL1LMNAKDM1A | |
| SCHEMBL12675417 | 0.78 | KCNA5 (0.46) | MAPK8MAPK1L3MBTL1LMNAKDM1A | |
| SCHEMBL6498283 | 0.77 | PPARG (0.41) | FAAHGAAL3MBTL1LMNAHPGD | |
| SCHEMBL30890827 | 0.77 | FAAH (0.46) | FAAHGAAL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL8507123 | 0.76 | HPGD (0.67) | L3MBTL1SMN1; SMN2HPGDHSD17B10RAB9A | |
| SCHEMBL17773307 | 0.76 | RAB9A (0.47) | FAAHL3MBTL1LMNASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| WO-2005016906-A1 | PROCESS FOR THE MANUFACTURE OF ROFECOXIB | SHASUN CHEMICALS AND DRUGS LIMITED (IN) | 2005-02-24 | — | — | WO | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |