Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | AGER | Q15109 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | RARG | P13631 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6505043 | 0.83 | L3MBTL1 (0.46) | KDM4ETDP1MAPTALDH1A1CYP3A4 | |
| SCHEMBL3436188 | 0.79 | KDM4E (0.63) | KDM4ETDP1MAPTALDH1A1CYP3A4 | |
| SCHEMBL6505414 | 0.77 | HPGD (0.47) | KDM4EMAPTALDH1A1L3MBTL1MYC | |
| SCHEMBL19207072 | 0.77 | NTRK1 (0.41) | KDM4ETDP1MAPTALDH1A1CYP3A4 | |
| SCHEMBL22617517 | 0.75 | KDM4E (0.42) | KDM4ETDP1L3MBTL1ADORA3MYC | |
| SCHEMBL3995172 | 0.74 | RARA (0.60) | KDM4EMAPTALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL13801128 | 0.74 | METAP2 (0.46) | KDM4EMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL6505435 | 0.73 | CYP3A4 (0.57) | KDM4EMAPTALDH1A1CYP3A4KMT2A | |
| SCHEMBL16041105 | 0.72 | HCRTR2 (0.43) | KDM4ETDP1MAPTALDH1A1CYP3A4 | |
| SCHEMBL130171 | 0.71 | KDM4E (0.61) | KDM4ETDP1MAPTALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1228327-C | Carboxylic acid derivatives and drugs containing the same | EISAI CO LTD (JP) | 2005-11-23 | — | — | CN | disclosed |
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| CN-1377336-A | Carboxylic acid derivatives and drugs containing the same | EISAI CO LTD (JP) | 2002-10-30 | — | — | CN | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |