Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6504891 | 0.83 | IKBKB (0.57) | IKBKBJAK2JAK3MEN1KMT2A | |
| SCHEMBL6506008 | 0.82 | IKBKB (0.56) | IKBKBJAK2JAK3MEN1KMT2A | |
| SCHEMBL19206637 | 0.81 | PARP1 (0.56) | IKBKBJAK2JAK3MEN1KMT2A | |
| SCHEMBL6506959 | 0.80 | KDM4E (0.47) | IKBKBJAK2JAK3MEN1KMT2A | |
| SCHEMBL6503091 | 0.80 | IKBKB (0.50) | IKBKBJAK2JAK3MEN1KMT2A | |
| SCHEMBL6508136 | 0.80 | IKBKB (0.60) | IKBKBJAK2JAK3MEN1KMT2A | |
| SCHEMBL6507728 | 0.80 | IKBKB (0.50) | IKBKBJAK2JAK3MEN1KMT2A | |
| SCHEMBL6505282 | 0.79 | MAPT (0.55) | IKBKBJAK2JAK3MEN1KMT2A | |
| SCHEMBL6510323 | 0.79 | HDAC1 (0.52) | IKBKBJAK2JAK3MEN1KMT2A | |
| SCHEMBL1681706 | 0.77 | IKBKB (0.67) | IKBKBJAK2JAK3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |