Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 7/20 | 0.56 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | CFTR | P13569 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6504891 | 0.85 | IKBKB (0.57) | IKBKBJAK2JAK3RAB9ANPC1 | |
| SCHEMBL6507659 | 0.82 | IKBKB (0.53) | IKBKBJAK2JAK3RAB9ANPC1 | |
| SCHEMBL6508136 | 0.82 | IKBKB (0.60) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6503091 | 0.82 | IKBKB (0.50) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6507070 | 0.82 | IKBKB (0.46) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6505282 | 0.81 | MAPT (0.55) | IKBKBJAK2JAK3RAB9ANPC1 | |
| SCHEMBL6530279 | 0.80 | IKBKB (0.48) | IKBKBJAK2JAK3RAB9ANPC1 | |
| SCHEMBL6506340 | 0.80 | FLT3 (0.51) | IKBKBJAK2JAK3RAB9ANPC1 | |
| SCHEMBL6509362 | 0.78 | OGG1 (0.54) | RAB9ANPC1MEN1KMT2AHDAC6 | |
| SCHEMBL7004222 | 0.78 | JAK2 (0.69) | IKBKBJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |