Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 6/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 3/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6514944 | 0.87 | KDM5A (0.37) | CHEK1KDM4EALDH1A1IKBKBMAPT | |
| SCHEMBL6506529 | 0.77 | KDM5A (0.36) | CHEK1IKBKB | |
| SCHEMBL6512268 | 0.77 | IKBKB (0.35) | CHEK1MAPK1IKBKB | |
| SCHEMBL6505484 | 0.76 | CHEK1 (0.55) | CHEK1ALDH1A1IKBKB | |
| SCHEMBL6505649 | 0.74 | IKBKB (0.45) | CHEK1IKBKB | |
| SCHEMBL6508772 | 0.73 | IKBKB (0.38) | CHEK1KDM4EIKBKB | |
| SCHEMBL28374051 | 0.68 | HDAC3 (0.47) | HPGDMAPK1KDM4EALDH1A1CSNK2A2 | |
| SCHEMBL29749792 | 0.68 | HDAC3 (0.47) | HPGDMAPK1KDM4EALDH1A1CSNK2A2 | |
| SCHEMBL6509499 | 0.66 | PTK2 (0.40) | MAPK1ALDH1A1MAPT | |
| SCHEMBL9722819 | 0.66 | ALDH1A1 (0.45) | HPGDMAPK1KDM4EALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |