Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL301111 | 0.89 | AKR1C1 (0.53) | CYP2D6CYP2C19AKR1C1OPRM1CYP3A4 | |
| SCHEMBL2703415 | 0.86 | USP2 (0.44) | CYP2D6USP2ALOX15CYP2C19ALDH1A1 | |
| SCHEMBL2079237 | 0.85 | AKR1C1 (0.65) | CYP2C19ALDH1A1AKR1C1CYP3A4APP | |
| SCHEMBL2535205 | 0.85 | AKR1C1 (0.59) | CYP2D6CYP2C19ALDH1A1AKR1C1OPRM1 | |
| SCHEMBL30487797 | 0.85 | AKR1C1 (0.65) | CYP2C19ALDH1A1AKR1C1CYP3A4APP | |
| SCHEMBL3219884 | 0.84 | AKR1C1 (0.62) | CYP2C19ALDH1A1AKR1C1CYP3A4APP | |
| SCHEMBL435932 | 0.84 | AKR1C1 (0.62) | CYP2C19ALDH1A1AKR1C1CYP3A4APP | |
| SCHEMBL373567 | 0.81 | AKR1C1 (0.68) | ALOX15CYP2C19AKR1C1OPRM1HSD11B1 | |
| SCHEMBL5768673 | 0.81 | AKR1C1 (0.46) | CYP2D6CYP2C19AKR1C1OPRM1CYP3A4 | |
| SCHEMBL1626768 | 0.81 | ALDH1A1 (0.48) | USP2CYP2C19ALDH1A1AKR1C1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. | 2005-06-30 | — | — | US | disclosed |
| WO-2003037271-A2 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREFOR | MILLENNIUM PHARMACEUTICALS,INC. (US) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | CCR8, CCL11, CCR5 | CYP2D6 1424/4885USP2 3886/4885ALOX15 388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.