Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 5/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ICMT | O60725 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6505457 | 0.94 | ITK (0.48) | ITKAURKADGAT1ALDH1A1SCN9A | |
| SCHEMBL6507055 | 0.91 | ITK (0.53) | ITKAURKADGAT1KDM4EUSP2 | |
| SCHEMBL6508745 | 0.89 | ITK (0.52) | ITKAURKAKDM4EALDH1A1SCN9A | |
| SCHEMBL6470662 | 0.87 | ITK (0.45) | ITKAURKAKDM4EALDH1A1SCN9A | |
| SCHEMBL6498382 | 0.87 | ITK (0.45) | ITKKDM4EALDH1A1SCN9AMAPT | |
| SCHEMBL6467910 | 0.84 | ITK (0.44) | ITKKDM4EALDH1A1SCN9AMAPT | |
| SCHEMBL6501255 | 0.84 | ITK (0.45) | ITKKDM4EALDH1A1SCN9AMAPT | |
| SCHEMBL6499548 | 0.84 | ITK (0.45) | ITKKDM4EALDH1A1SCN9AMAPT | |
| SCHEMBL6504845 | 0.83 | ITK (0.46) | ITKKDM4EALDH1A1SCN9AMAPT | |
| SCHEMBL6468754 | 0.83 | ITK (0.43) | ITKKDM4EALDH1A1SCN9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | PHARMACIA AND UPJOHN COMPANY LLC | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | IL4, ARG2, CASP4 | ITK 4236/4885AURKA 3499/4885DGAT1 4389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.