Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6505457 | 0.95 | ITK (0.48) | ITKALDH1A1TSHRMAPK10NOTUM | |
| SCHEMBL6506609 | 0.91 | ITK (0.49) | ITKALDH1A1DGAT1KDM4EAURKA | |
| SCHEMBL6497552 | 0.83 | IRAK4 (0.54) | ITKALDH1A1TSHRUSP2SMN1; SMN2 | |
| SCHEMBL6503646 | 0.83 | ITK (0.51) | ITKALDH1A1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL6468065 | 0.82 | ITK (0.43) | ITKALDH1A1TSHRMAPK10KDM4E | |
| SCHEMBL6505234 | 0.82 | ITK (0.49) | ITKALDH1A1KDM4ESMN1; SMN2HTT | |
| SCHEMBL6472892 | 0.81 | TP53 (0.54) | ITKALDH1A1KDM4ESMN1; SMN2HTT | |
| SCHEMBL6470268 | 0.81 | ITK (0.42) | ITKALDH1A1TSHRMAPK10KDM4E | |
| SCHEMBL6465874 | 0.81 | ITK (0.44) | ITKALDH1A1TSHRKDM4ESMN1; SMN2 | |
| SCHEMBL6467585 | 0.81 | SCN9A (0.44) | ITKALDH1A1TSHRMAPK10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | PHARMACIA AND UPJOHN COMPANY LLC | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | IL4, ARG2, CASP4 | ITK 4236/4885ALDH1A1 846/4885TSHR 1759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.