Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 4/20 | 0.59 |
| ▸ | KYNU | Q16719 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 7/20 | 0.47 |
| ▸ | CTSL | P07711 | 4/20 | 0.47 |
| ▸ | CTSB | P07858 | 3/20 | 0.47 |
| ▸ | CTSS | P25774 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8142600 | 0.97 | CASP1 (0.56) | CASP1KYNULMNAALDH1A1ALOX15 | |
| SCHEMBL10443427 | 0.91 | CASP1 (0.61) | CASP1LMNAOPRK1CTSKCTSL | |
| SCHEMBL10443426 | 0.91 | CASP1 (0.61) | CASP1LMNAOPRK1CTSKCTSL | |
| SCHEMBL8142582 | 0.88 | CASP1 (0.58) | CASP1OPRK1CTSKCTSLCTSB | |
| SCHEMBL12023182 | 0.83 | CASP1 (0.53) | CASP1LMNAOPRK1CTSKCTSL | |
| SCHEMBL29440261 | 0.82 | KYNU (0.51) | CASP1KYNUALDH1A1ALOX15OPRK1 | |
| SCHEMBL29062923 | 0.81 | ALDH1A1 (0.50) | CASP1KYNUALDH1A1ALOX15OPRK1 | |
| SCHEMBL29062922 | 0.81 | ALDH1A1 (0.50) | CASP1KYNUALDH1A1ALOX15OPRK1 | |
| SCHEMBL7413795 | 0.79 | CASP1 (0.74) | CASP1 | |
| SCHEMBL6497607 | 0.78 | CASP1 (0.61) | CASP1KYNUALDH1A1ALOX15CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |
| EP-0350163-A2 | Renin inhibitory peptides | BEECHAM GROUP PLC (GB) | 1990-01-10 | — | — | EP | disclosed |