Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | BAD | Q92934 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.33 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.33 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3468323 | 0.83 | RELA (0.50) | ESR1MEN1KMT2AESR2PGR | |
| SCHEMBL3468317 | 0.83 | RELA (0.50) | ESR1MEN1KMT2AESR2PGR | |
| SCHEMBL3468563 | 0.78 | MMP3 (0.47) | ESR1MEN1KMT2AESR2BCL2L1 | |
| SCHEMBL3467807 | 0.77 | ESR1 (0.55) | ESR1MEN1KMT2AESR2PGR | |
| SCHEMBL3467812 | 0.77 | ESR1 (0.55) | ESR1MEN1KMT2AESR2PGR | |
| SCHEMBL3468706 | 0.76 | KMO (0.47) | ESR1MEN1KMT2ALMNAMAPT | |
| SCHEMBL3468080 | 0.73 | ESR1 (0.51) | ESR1MEN1KMT2ABCL2L1BAD | |
| SCHEMBL3075249 | 0.73 | ESR1 (0.49) | ESR1ESR2PGRMAPTCA1 | |
| SCHEMBL3075252 | 0.73 | ESR1 (0.49) | ESR1ESR2PGRMAPTCA1 | |
| SCHEMBL27640751 | 0.73 | ESR1 (0.39) | ESR1MEN1KMT2AESR2BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005012220-A9 | CYCLOALKYLIDENE COMPOUNDS AS MODULATORS OF ESTROGEN RECEPTOR | SMITHKLINE BEECHAM CORP (US) | 2005-05-19 | — | — | WO | disclosed |