Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 8/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6507659 | 0.80 | IKBKB (0.53) | KDM4EALDH1A1HPGDPOLBIKBKB | |
| SCHEMBL31599466 | 0.75 | ALDH1A1 (0.69) | KDM4EALDH1A1HPGDPOLBMEN1 | |
| SCHEMBL6504891 | 0.73 | IKBKB (0.57) | KDM4EALDH1A1HPGDIKBKBJAK2 | |
| SCHEMBL6506008 | 0.72 | IKBKB (0.56) | HPGDPOLBIKBKBJAK2JAK3 | |
| SCHEMBL6509110 | 0.72 | IKBKB (0.63) | KDM4EALDH1A1POLBIKBKBJAK2 | |
| SCHEMBL6512362 | 0.72 | IKBKB (0.57) | ALDH1A1POLBIKBKBJAK2JAK3 | |
| SCHEMBL6506347 | 0.72 | IKBKB (0.61) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6530279 | 0.71 | IKBKB (0.48) | KDM4EALDH1A1HPGDPOLBIKBKB | |
| SCHEMBL6508136 | 0.71 | IKBKB (0.60) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6503091 | 0.71 | IKBKB (0.50) | IKBKBJAK2JAK3MEN1EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |
| WO-2005081960-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |