Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6512024 | 0.85 | ALDH1A1 (0.40) | KMT2AALDH1A1MEN1NPSR1LMNA | |
| SCHEMBL6513922 | 0.83 | TDP1 (0.38) | KMT2AALDH1A1MEN1NPSR1LMNA | |
| SCHEMBL6507666 | 0.74 | HPGD (0.48) | KMT2AALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL6510406 | 0.73 | TDP1 (0.38) | KMT2AALDH1A1MEN1LMNAMAPT | |
| SCHEMBL6510442 | 0.71 | PTGES (0.37) | KMT2AALDH1A1MEN1LMNASMN1; SMN2 | |
| SCHEMBL6510440 | 0.71 | PTGES (0.37) | KMT2AALDH1A1MEN1LMNASMN1; SMN2 | |
| SCHEMBL6509288 | 0.70 | ATM (0.35) | ALDH1A1LMNASMN1; SMN2MAPTTP53 | |
| SCHEMBL6509294 | 0.70 | ATM (0.35) | ALDH1A1LMNASMN1; SMN2MAPTTP53 | |
| SCHEMBL6507866 | 0.68 | HTT (0.34) | KMT2AALDH1A1MEN1NPSR1LMNA | |
| SCHEMBL6531846 | 0.66 | HPGD (0.44) | ALDH1A1SMN1; SMN2MAPTPOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |