Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | PPM1G | O15355 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | PPM1A | P35813 | 1/20 | 0.37 |
| ▸ | PTPN9 | P43378 | 1/20 | 0.37 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.37 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.37 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | CTRC | Q99895 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6510442 | 1.00 | PTGES (0.37) | PTGESPPM1GALOX5PTPN1KDM5A | |
| SCHEMBL6509288 | 0.91 | ATM (0.35) | PTGESPPM1GALOX5PTPN1KDM5A | |
| SCHEMBL6509294 | 0.91 | ATM (0.35) | PTGESPPM1GALOX5PTPN1KDM5A | |
| SCHEMBL6508234 | 0.79 | HPGD (0.37) | MAPTTP53RXFP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6511358 | 0.73 | NPR3 (0.45) | MAPT | |
| SCHEMBL6511364 | 0.73 | NPR3 (0.45) | MAPT | |
| SCHEMBL6510069 | 0.71 | HPGD (0.39) | MAPTTP53RXFP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6510073 | 0.71 | HPGD (0.39) | MAPTTP53RXFP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6507668 | 0.71 | KMT2A (0.41) | MAPTTP53SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6514102 | 0.71 | HPGD (0.40) | MAPTTP53RXFP1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | claimed |
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |