Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6531846 | 0.87 | HPGD (0.44) | HPGDSMN1; SMN2L3MBTL1MAPTALDH1A1 | |
| SCHEMBL6512023 | 0.85 | ALDH1A1 (0.40) | HPGDSMN1; SMN2L3MBTL1MAPTALDH1A1 | |
| SCHEMBL6513920 | 0.84 | CTSK (0.40) | HPGDSMN1; SMN2L3MBTL1MAPTALDH1A1 | |
| SCHEMBL6511358 | 0.80 | NPR3 (0.45) | MAPT | |
| SCHEMBL6511364 | 0.80 | NPR3 (0.45) | MAPT | |
| SCHEMBL6510400 | 0.74 | HPGD (0.44) | HPGDALDH1A1KDM4EHSD17B10GAA | |
| SCHEMBL6507668 | 0.74 | KMT2A (0.41) | HPGDSMN1; SMN2L3MBTL1MAPTALDH1A1 | |
| SCHEMBL6531904 | 0.70 | HPGD (0.46) | HPGDSMN1; SMN2L3MBTL1MAPTALDH1A1 | |
| SCHEMBL6513091 | 0.70 | HPGD (0.46) | HPGDSMN1; SMN2L3MBTL1MAPTALDH1A1 | |
| SCHEMBL6507865 | 0.68 | HTT (0.41) | HPGDSMN1; SMN2L3MBTL1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |