Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nabumetone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | ESR1 | P03372 | 5/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nabumetone SCHEMBL1649175 | 0.83 | CYP1A2 (0.81) | MAPTNPC1RAB9AKDM4ELMNA | |
| SCHEMBL25135 | 0.77 | KMT2A (0.77) | MAPTRAB9AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL29392731 | 0.77 | KMT2A (0.77) | MAPTRAB9AKDM4ELMNASMN1; SMN2 | |
| Nabumetone SCHEMBL29373228 | 0.77 | CYP1A2 (1.00) | MAPTNPC1RAB9AKDM4ELMNA | |
| Nabumetone SCHEMBL2256 | 0.77 | CYP1A2 (1.00) | MAPTNPC1RAB9AKDM4ELMNA | |
| Nabumetone SCHEMBL29570823 | 0.77 | CYP1A2 (1.00) | MAPTNPC1RAB9AKDM4ELMNA | |
| Nabumetone SCHEMBL3853067 | 0.77 | CYP1A2 (1.00) | MAPTNPC1RAB9AKDM4ELMNA | |
| SCHEMBL22283497 | 0.76 | HPGD (0.59) | MAPTNPC1RAB9AKDM4ELMNA | |
| Nabumetone SCHEMBL3362072 | 0.76 | RAB9A (0.86) | MAPTNPC1RAB9AKDM4ELMNA | |
| Nabumetone SCHEMBL7554060 | 0.76 | CYP1A2 (0.91) | MAPTNPC1RAB9AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005054204-A2 | PHARMACEUTICAL COMPOUNDS THAT REGENERATE IN VIVO | SYNCHRONY BIOSCIENCES, INC. (US) | 2005-06-16 | — | — | WO | disclosed |