Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 8/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | COMT | P21964 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6530157 | 0.85 | HPSE (0.77) | HPSEKDM4EALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL6529336 | 0.84 | HPSE (0.73) | HPSEKDM4EALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL6528477 | 0.83 | HDAC3 (0.62) | HPSEKDM4EALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL6532368 | 0.82 | HDAC3 (0.64) | HPSEKDM4EALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL6529482 | 0.82 | HPSE (0.59) | HPSEKDM4EALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL6514739 | 0.81 | MMP2 (0.80) | HPSEKDM4EALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL943034 | 0.81 | HPSE (1.00) | HPSEKDM4EALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL6533676 | 0.81 | HPSE (1.00) | HPSEKDM4EALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL6532397 | 0.80 | NPC1 (0.65) | HPSEKDM4EALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL16148198 | 0.80 | SMN1; SMN2 (0.61) | HPSEHIF1AKDM4EALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042495-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-PHENYL-UREA COMPOUNDS AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |