Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | TP53 | P04637 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6528477 | 0.89 | HDAC3 (0.62) | NPC1SMN1; SMN2RAB9ATP53ALDH1A1 | |
| SCHEMBL6532368 | 0.87 | HDAC3 (0.64) | NPC1SMN1; SMN2ALDH1A1HDAC3HDAC4 | |
| SCHEMBL6506624 | 0.84 | HPSE (0.68) | NPC1SMN1; SMN2RAB9ATP53ALDH1A1 | |
| SCHEMBL6529482 | 0.81 | HPSE (0.59) | NPC1SMN1; SMN2RAB9ATP53ALDH1A1 | |
| SCHEMBL6508327 | 0.80 | HPSE (0.66) | NPC1SMN1; SMN2RAB9AALDH1A1MAPT | |
| SCHEMBL643747 | 0.80 | NPC1 (1.00) | NPC1SMN1; SMN2RAB9ATP53ALDH1A1 | |
| SCHEMBL6530461 | 0.78 | KDM4E (0.70) | NPC1SMN1; SMN2RAB9ATP53ALDH1A1 | |
| SCHEMBL6514739 | 0.78 | MMP2 (0.80) | NPC1SMN1; SMN2RAB9ATP53ALDH1A1 | |
| SCHEMBL6527951 | 0.77 | HPSE (0.61) | NPC1SMN1; SMN2RAB9AALDH1A1HDAC3 | |
| SCHEMBL6527955 | 0.76 | NPC1 (0.69) | NPC1SMN1; SMN2RAB9ATP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042496-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-BENZYL-AMINE DERIVATIVES AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |