Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 8/20 | 0.58 |
| ▸ | NPC1 | O15118 | 7/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 3/20 | 0.55 |
| ▸ | MMP13 | P45452 | 3/20 | 0.55 |
| ▸ | MMP9 | P14780 | 2/20 | 0.55 |
| ▸ | MMP8 | P22894 | 2/20 | 0.55 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6527955 | 0.93 | NPC1 (0.69) | HPSERAB9ANPC1GAAKDM4E | |
| SCHEMBL6533101 | 0.93 | NPC1 (0.56) | HPSERAB9ANPC1GAAKDM4E | |
| SCHEMBL6530461 | 0.89 | KDM4E (0.70) | HPSERAB9ANPC1KDM4ESMN1; SMN2 | |
| SCHEMBL6527951 | 0.88 | HPSE (0.61) | HPSERAB9ANPC1KDM4ESMN1; SMN2 | |
| SCHEMBL6514739 | 0.86 | MMP2 (0.80) | HPSERAB9ANPC1KDM4ESMN1; SMN2 | |
| SCHEMBL6532368 | 0.85 | HDAC3 (0.64) | HPSENPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL6530991 | 0.85 | ALDH1A1 (0.51) | HPSERAB9ANPC1GAAKDM4E | |
| SCHEMBL6506624 | 0.84 | HPSE (0.68) | HPSERAB9ANPC1KDM4ESMN1; SMN2 | |
| SCHEMBL5879606 | 0.84 | RAB9A (0.60) | HPSERAB9ANPC1GAAKDM4E | |
| SCHEMBL6508327 | 0.82 | HPSE (0.66) | HPSERAB9ANPC1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042496-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-BENZYL-AMINE DERIVATIVES AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |