Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bupranolol SCHEMBL29518497 | 1.00 | L3MBTL1 (0.63) | L3MBTL1MEN1HTTKMT2ANPSR1 | |
| Bupranolol SCHEMBL34061 | 1.00 | L3MBTL1 (0.63) | L3MBTL1MEN1HTTKMT2ANPSR1 | |
| Bupranolol SCHEMBL2497819 | 1.00 | L3MBTL1 (0.63) | L3MBTL1MEN1HTTKMT2ANPSR1 | |
| Bupranolol SCHEMBL123717 | 1.00 | L3MBTL1 (0.63) | L3MBTL1MEN1HTTKMT2ANPSR1 | |
| Bupranolol SCHEMBL348360 | 0.99 | L3MBTL1 (0.65) | L3MBTL1MEN1HTTKMT2ANPSR1 | |
| Bupranolol SCHEMBL348362 | 0.99 | L3MBTL1 (0.65) | L3MBTL1MEN1HTTKMT2ANPSR1 | |
| SCHEMBL348361 | 0.92 | L3MBTL1 (0.63) | L3MBTL1MEN1HTTKMT2ANPSR1 | |
| Bupranolol SCHEMBL8908385 | 0.90 | L3MBTL1 (0.53) | L3MBTL1MEN1HTTKMT2ANPSR1 | |
| Bupranolol SCHEMBL19816741 | 0.89 | LMNA (0.55) | L3MBTL1MEN1HTTKMT2ANPSR1 | |
| SCHEMBL12215557 | 0.88 | SLC2A1 (0.57) | L3MBTL1MEN1HTTKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005099699-A1 | COMBINATION OF (S)-AMLODIPINE AND A BETA-BLOCKER, AND METHODS FOR REDUCING HYPERTENSION | SEPRACOR INC. (US) | 2005-10-27 | — | — | WO | disclosed |