SCHEMBL6508554

SCHEMBL6508554

CCOC(=O)CCc1cccc(C#CCN2C(=O)c3ccccc3NC2C)c1OCC

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.43
KDM4E B2RXH2 7/20 0.43
GAA P10253 5/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
CYP4F2 P78329 1/20 0.38
CYP4A11 Q02928 1/20 0.38
HPGD P15428 5/20 0.38
NPSR1 Q6W5P4 4/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
DRD2 P14416 1/20 0.38
USP2 O75604 1/20 0.38
CYP2C9 P11712 2/20 0.38
CYP2C19 P33261 2/20 0.38
CYP3A4 P08684 1/20 0.38
PTPN1 P18031 2/20 0.37
KMT2A Q03164 2/20 0.36
MEN1 O00255 1/20 0.36
GSK3B P49841 1/20 0.35
THRB P10828 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6507803 0.81 ALDH1A1 (0.40) ALDH1A1KDM4EGAASMN1; SMN2HPGD
SCHEMBL6510219 0.76 CYP4F2 (0.46) ALDH1A1KDM4EGAACYP4F2CYP4A11
SCHEMBL6506652 0.74 CYP4F2 (0.41) ALDH1A1KDM4EGAACYP4F2CYP4A11
SCHEMBL6528531 0.73 NOTUM (0.46) ALDH1A1KDM4EGAACYP4F2CYP4A11
SCHEMBL6529673 0.72 ALDH1A1 (0.49) ALDH1A1GAACYP4F2CYP4A11USP2
SCHEMBL6528363 0.71 MAPT (0.38) ALDH1A1GAACYP4F2CYP4A11HPGD
SCHEMBL6508551 0.68 KDM4E (0.44) ALDH1A1KDM4EGAASMN1; SMN2HPGD
SCHEMBL6532064 0.68 ALDH1A1 (0.43) ALDH1A1KDM4EGAASMN1; SMN2HPGD
SCHEMBL6718325 0.66 CYP4F2 (0.59) ALDH1A1KDM4EGAASMN1; SMN2CYP4F2
SCHEMBL14259786 0.63 ALDH1A1 (0.51) ALDH1A1KDM4EGAASMN1; SMN2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005100318-A1 ALKANOIC ACIDS AND THEIR ESTERS AS ANTIDIABETIC AGENTS RANBAXY LABORATORIES LIMITED (US) 2005-10-27 WO claimed
WO-2005100318-A1 ALKANOIC ACIDS AND THEIR ESTERS AS ANTIDIABETIC AGENTS RANBAXY LABORATORIES LIMITED (US) 2005-10-27 WO disclosed