Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6509392 | 0.86 | MAPT (0.43) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 | |
| SCHEMBL6508660 | 0.85 | MAPK1 (0.52) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 | |
| SCHEMBL6510588 | 0.81 | LMNA (0.50) | SMN1; SMN2NPC1RAB9ALMNASIGMAR1 | |
| SCHEMBL6507347 | 0.81 | LMNA (0.52) | SMN1; SMN2NPC1RAB9ALMNASIGMAR1 | |
| SCHEMBL6511304 | 0.81 | MAPT (0.45) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 | |
| SCHEMBL5922994 | 0.78 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 | |
| SCHEMBL6508617 | 0.76 | SIGMAR1 (0.46) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6507985 | 0.76 | NPC1 (0.47) | SMN1; SMN2NPC1RAB9AL3MBTL1SIGMAR1 | |
| SCHEMBL6507406 | 0.74 | RAB9A (0.52) | SMN1; SMN2NPC1RAB9ALMNASIGMAR1 | |
| SCHEMBL4100977 | 0.73 | SIGMAR1 (0.55) | SMN1; SMN2LMNAL3MBTL1SIGMAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095345-A2 | HETEROARYL GUANIDINES AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2005-10-13 | — | — | WO | claimed |