Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | NPY1R | P25929 | 1/20 | 0.54 |
| ▸ | NPY2R | P49146 | 1/20 | 0.54 |
| ▸ | CTSV | O60911 | 2/20 | 0.52 |
| ▸ | CTSL | P07711 | 2/20 | 0.52 |
| ▸ | PARP1 | P09874 | 2/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3121586 | 0.80 | CA12 (0.56) | CA12CA9MAPTALDH1A1MEN1 | |
| SCHEMBL27939168 | 0.78 | KIF11 (0.54) | CA12CA9MAPTALDH1A1MEN1 | |
| SCHEMBL11543395 | 0.77 | MAPT (0.67) | CA12CA9MAPTALDH1A1MEN1 | |
| SCHEMBL6908303 | 0.77 | ALDH1A1 (0.53) | CA12CA9MAPTALDH1A1MEN1 | |
| SCHEMBL29672461 | 0.76 | MAPT (0.61) | CA12CA9MAPTALDH1A1MEN1 | |
| SCHEMBL266008 | 0.76 | MAPT (0.61) | CA12CA9MAPTALDH1A1MEN1 | |
| SCHEMBL30349881 | 0.76 | MAPT (0.61) | CA12CA9MAPTALDH1A1MEN1 | |
| SCHEMBL29540314 | 0.76 | GABRA1 (0.70) | CA12CA9MAPTALDH1A1MEN1 | |
| SCHEMBL155013 | 0.76 | GABRA1 (0.70) | CA12CA9MAPTALDH1A1MEN1 | |
| SCHEMBL2993366 | 0.75 | ALDH1A1 (0.60) | CA12CA9MAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005035526-A1 | BICYCLIC COMPOUNDS AND THEIR THERAPEUTIC USE | ARGENTA DISCOVERY LTD. (GB) | 2005-04-21 | — | — | WO | disclosed |