Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 10/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6262972 | 0.84 | CHEK2 (0.69) | CHEK2MEN1KMT2A | |
| SCHEMBL6509847 | 0.81 | TCF4 (0.52) | CHEK2NPC1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL13836492 | 0.80 | CHEK2 (0.61) | CHEK2 | |
| SCHEMBL1664788 | 0.80 | CHEK2 (0.68) | CHEK2ALDH1A1NPC1SMN1; SMN2PKM | |
| SCHEMBL6529784 | 0.80 | HPSE (0.61) | CHEK2 | |
| SCHEMBL6262977 | 0.79 | NPC1 (0.79) | CHEK2ALDH1A1NPC1SMN1; SMN2PKM | |
| SCHEMBL5250965 | 0.79 | CHEK2 (0.65) | CHEK2ALDH1A1NPC1SMN1; SMN2PKM | |
| SCHEMBL6508734 | 0.78 | KDM4E (0.59) | CHEK2ALDH1A1NPC1SMN1; SMN2PKM | |
| SCHEMBL17393422 | 0.77 | CHEK2 (0.57) | CHEK2ALDH1A1NPC1SMN1; SMN2PKM | |
| SCHEMBL17393425 | 0.77 | CHEK2 (0.57) | CHEK2ALDH1A1NPC1SMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042495-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-PHENYL-UREA COMPOUNDS AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |