Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TCF4 | P15884 | 1/20 | 0.52 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 7/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6247109 | 0.83 | CHEK2 (0.70) | CHEK2NR4A2 | |
| SCHEMBL6509068 | 0.81 | CHEK2 (0.53) | CHEK2KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6508734 | 0.81 | KDM4E (0.59) | CHEK2KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6529784 | 0.81 | HPSE (0.61) | CHEK2HPSE | |
| SCHEMBL4373640 | 0.80 | KDM4E (0.69) | TCF4CTNNB1CHEK2NR4A2KDM4E | |
| SCHEMBL29506637 | 0.80 | TCF4 (0.79) | TCF4CTNNB1NR4A2KDM4ENPC1 | |
| SCHEMBL18712778 | 0.80 | TCF4 (0.79) | TCF4CTNNB1NR4A2KDM4ENPC1 | |
| SCHEMBL6247115 | 0.78 | SMN1; SMN2 (0.61) | TCF4CTNNB1CHEK2KDM4ENPC1 | |
| SCHEMBL17370972 | 0.77 | TCF4 (0.59) | TCF4CTNNB1NR4A2KDM4ENPC1 | |
| SCHEMBL6528395 | 0.77 | HPSE (0.68) | KDM4EHPSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042495-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-PHENYL-UREA COMPOUNDS AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |