Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 1/20 | 0.61 |
| ▸ | GUSB | P08236 | 8/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 9/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6509847 | 0.81 | TCF4 (0.52) | HPSECHEK2 | |
| SCHEMBL6509068 | 0.80 | CHEK2 (0.53) | CHEK2 | |
| SCHEMBL6508734 | 0.80 | KDM4E (0.59) | HPSECHEK2 | |
| SCHEMBL6511295 | 0.78 | MGAM (0.63) | HPSE | |
| SCHEMBL6325549 | 0.77 | ALDH1A1 (0.68) | HPSEGUSB | |
| SCHEMBL7393557 | 0.77 | GUSB (0.79) | HPSEGUSB | |
| SCHEMBL11331915 | 0.77 | HPSE (0.65) | HPSEGUSBCHEK2MITFOPRM1 | |
| SCHEMBL25722414 | 0.77 | HPSE (0.64) | HPSEGUSBCHEK2 | |
| Hydrochloric Acid SCHEMBL10736606 | 0.76 | GUSB (0.77) | HPSEGUSB | |
| SCHEMBL6530825 | 0.76 | HPSE (1.00) | HPSEGUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042495-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-PHENYL-UREA COMPOUNDS AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |