Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 5/20 | 0.42 |
| ▸ | PPARG | P37231 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CNOT7 | Q9UIV1 | 4/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6511112 | 0.91 | PPARA (0.42) | PPARAPPARGALDH1A1AGTR1AGTR2 | |
| SCHEMBL6509376 | 0.90 | PPARA (0.42) | PPARAPPARGADORA3 | |
| SCHEMBL6508985 | 0.89 | PPARA (0.40) | PPARAPPARGHTTALDH1A1CNOT7 | |
| SCHEMBL6511617 | 0.89 | PPARA (0.44) | PPARAPPARGL3MBTL1HTTALDH1A1 | |
| SCHEMBL3286592 | 0.86 | PPARA (0.41) | PPARAPPARGCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6516926 | 0.86 | PPARA (0.62) | PPARAPPARGCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6511817 | 0.86 | PPARA (0.62) | PPARAPPARGCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3284363 | 0.84 | PPARA (0.40) | PPARAPPARGCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3285942 | 0.84 | PPARA (0.42) | PPARAPPARGALDH1A1ADORA3TP53 | |
| SCHEMBL3284391 | 0.82 | PPARA (0.38) | PPARAPPARGCYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005080354-A1 | 1,2,4-TRIAZINES DERIVATIVES, PREPARATION THEREOF AND USE THEREOF IN HUMAN THERAPEUTICS | PIERRE FABRE MEDICAMENT (FR) | 2005-09-01 | — | — | WO | claimed |
| WO-2005080354-A1 | 1,2,4-TRIAZINES DERIVATIVES, PREPARATION THEREOF AND USE THEREOF IN HUMAN THERAPEUTICS | PIERRE FABRE MEDICAMENT (FR) | 2005-09-01 | — | — | WO | disclosed |