Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 8/20 | 0.42 |
| ▸ | PPARG | P37231 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6509688 | 0.91 | PPARA (0.42) | PPARAPPARGALDH1A1AGTR1AGTR2 | |
| SCHEMBL6508985 | 0.88 | PPARA (0.40) | PPARAPPARGALDH1A1AGTR1AGTR2 | |
| SCHEMBL3284363 | 0.87 | PPARA (0.40) | PPARAPPARGALDH1A1MEN1KMT2A | |
| SCHEMBL6509376 | 0.85 | PPARA (0.42) | PPARAPPARGMEN1KMT2A | |
| SCHEMBL6511129 | 0.85 | PPARA (0.64) | PPARAPPARGALDH1A1PPARD | |
| SCHEMBL6511617 | 0.84 | PPARA (0.44) | PPARAPPARGALDH1A1AGTR1AGTR2 | |
| SCHEMBL6509731 | 0.83 | PPARA (0.64) | PPARAPPARGALDH1A1AGTR1AGTR2 | |
| SCHEMBL6512786 | 0.83 | PPARA (0.64) | PPARAPPARGALDH1A1AGTR1AGTR2 | |
| SCHEMBL6533130 | 0.83 | PPARA (0.64) | PPARAPPARGALDH1A1AGTR1AGTR2 | |
| SCHEMBL6515640 | 0.83 | MEN1 (0.37) | PPARAALDH1A1MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005080354-A1 | 1,2,4-TRIAZINES DERIVATIVES, PREPARATION THEREOF AND USE THEREOF IN HUMAN THERAPEUTICS | PIERRE FABRE MEDICAMENT (FR) | 2005-09-01 | — | — | WO | claimed |
| WO-2005080354-A1 | 1,2,4-TRIAZINES DERIVATIVES, PREPARATION THEREOF AND USE THEREOF IN HUMAN THERAPEUTICS | PIERRE FABRE MEDICAMENT (FR) | 2005-09-01 | — | — | WO | disclosed |