Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.57 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 4/20 | 0.55 |
| ▸ | HTR2B | P41595 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | PRKX | P51817 | 1/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.45 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6510804 | 1.00 | S1PR1 (0.57) | S1PR1S1PR5PDGFRAPIM1HTR2C | |
| SCHEMBL6509995 | 0.88 | HTR2C (0.60) | S1PR1S1PR5HTR2CHTR2BMAOB | |
| SCHEMBL6508988 | 0.87 | HTR2C (0.73) | S1PR1S1PR5PDGFRAHTR2CHTR2B | |
| SCHEMBL6511035 | 0.87 | HTR2C (0.73) | S1PR1S1PR5PDGFRAHTR2CHTR2B | |
| SCHEMBL15833076 | 0.87 | HTR2C (0.61) | HTR2CHTR2BMAOBNR4A2MAPT | |
| SCHEMBL7314615 | 0.81 | HTR2C (0.60) | HTR2CHTR2BLMNAGID4 | |
| SCHEMBL6511003 | 0.80 | HTR2C (0.73) | S1PR1S1PR5PDGFRAHTR2CHTR2B | |
| SCHEMBL15832942 | 0.80 | HTR2C (0.67) | HTR2CHTR2BMAOBGID4HDAC3 | |
| SCHEMBL6510792 | 0.77 | HTR2C (0.64) | HTR2CHTR2BMAOBNR4A2GID4 | |
| SCHEMBL6511220 | 0.77 | HTR2C (0.64) | HTR2CHTR2BMAOBNR4A2GID4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040108-A1 | PROLINAMIDE DERIVATIVES AS SODIUM AND/OR CALCIUM CHANNEL BLOCKERS OR SELECTIVE MAO-B INHIBITORS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2005-05-06 | — | — | WO | claimed |
| WO-2005040108-A1 | PROLINAMIDE DERIVATIVES AS SODIUM AND/OR CALCIUM CHANNEL BLOCKERS OR SELECTIVE MAO-B INHIBITORS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2005-05-06 | — | — | WO | disclosed |