SCHEMBL6510043

SCHEMBL6510043

C[Si](C)(C)C#Cc1ccc(-c2ccc(C#C[Si](C)(C)C)cc2[N+](=O)[O-])c([N+](=O)[O-])c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
VCAM1 P19320 2/20 0.39
P2RY6 Q15077 1/20 0.35
MAPT P10636 4/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
GABRA1 P14867 1/20 0.34
GABRG2 P18507 1/20 0.34
GABRB3 P28472 1/20 0.34
GABRA5 P31644 1/20 0.34
GABRA3 P34903 1/20 0.34
GABRA2 P47869 1/20 0.34
S1PR1 P21453 1/20 0.34
CYP3A4 P08684 1/20 0.34
TSHR P16473 1/20 0.34
NPC1 O15118 2/20 0.34
HPGD P15428 2/20 0.34
RAB9A P51151 2/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
ALDH1A1 P00352 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6511117 0.91 CYP1A2 (0.39) VCAM1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL9264032 0.88 ALDH1A1 (0.49) MAPTGABRA1GABRG2GABRB3GABRA5
SCHEMBL1507617 0.85 ALDH1A1 (0.49) VCAM1MAPTCYP3A4TSHRNPC1
SCHEMBL2685005 0.84 VCAM1 (0.59) VCAM1MAPTHPGDALDH1A1
SCHEMBL2398877 0.84 TSHR (0.51) MAPTCYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL15687843 0.84 ALDH1A1 (0.49) VCAM1P2RY6MAPTCYP1A2CYP2C19
SCHEMBL21753062 0.83 PDK1 (0.43) VCAM1P2RY6MAPTCYP1A2CYP2C19
SCHEMBL1068908 0.81 TDP1 (0.50) MAPTCYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL12226837 0.79 CYP1A2 (0.35) VCAM1P2RY6CYP1A2CYP2C19GABRA1
SCHEMBL23850829 0.79 GAA (0.57) MAPTRAB9ASMN1; SMN2ALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050101063-A1 Three-terminal field-controlled molecular devices TOUR JAMES M (US) 2005-05-12 US disclosed
WO-2002035580-A2 THREE-TERMINAL FIELD-CONTROLLED MOLECULAR DEVICES MOLECULAR ELECTRONICS CORPORATION (US) 2002-05-02 WO disclosed