Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1068908 | 0.88 | TDP1 (0.50) | TSHRMAPTTDP1MEN1POLB | |
| SCHEMBL6511117 | 0.85 | CYP1A2 (0.39) | TSHRMAPTTDP1MEN1POLB | |
| SCHEMBL6510043 | 0.84 | VCAM1 (0.39) | TSHRMAPTTDP1ALDH1A1CYP3A4 | |
| SCHEMBL1507617 | 0.83 | ALDH1A1 (0.49) | TSHRMAPTMEN1POLBKMT2A | |
| SCHEMBL2685005 | 0.81 | VCAM1 (0.59) | MAPTMEN1KMT2AALDH1A1PKM | |
| SCHEMBL15687843 | 0.81 | ALDH1A1 (0.49) | MAPTTDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL21753062 | 0.80 | PDK1 (0.43) | TSHRMAPTTDP1MEN1POLB | |
| SCHEMBL18784932 | 0.78 | TSHR (0.51) | TSHRMAPTTDP1MEN1POLB | |
| SCHEMBL9356251 | 0.78 | CASP3 (0.54) | TSHRMAPTTDP1MEN1POLB | |
| SCHEMBL12226837 | 0.77 | CYP1A2 (0.35) | TSHRTDP1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10961202-B2 | Bis-benzimidazole compounds and methods of using the same | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-03-30 | — | — | US | disclosed |
| EP-3710442-A2 | BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING THE SAME | The Scripps Research Institute (US) | 2020-09-23 | — | — | EP | disclosed |
| US-20190152924-A1 | BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING THE SAME | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2019-05-23 | — | — | US | disclosed |
| US-9890327-B2 | Phosphorescent transition metal complex, its preparation and use | CITY UNIVERSITY OF HONG KONG (HK) | 2018-02-13 | — | — | US | disclosed |
| EP-2981533-B1 | PROTEIN KINASE INHIBITORS | ORION CORP (FI) | 2017-12-06 | — | — | EP | disclosed |
| US-20170114275-A1 | PHOSPHORESCENT TRANSITION METAL COMPLEX, ITS PREPARATION AND USE | CITY UNIVERSITY OF HONG KONG (HK) | 2017-04-27 | — | — | US | disclosed |
| EP-2542549-B1 | INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2016-05-11 | — | — | EP | disclosed |
| EP-2981533-A1 | PROTEIN KINASE INHIBITORS | Orion Corporation (FI) | 2016-02-10 | — | — | EP | disclosed |
| US-20160031855-A1 | PROTEIN KINASE INHIBITORS | ORION CORPORATION (FI) | 2016-02-04 | — | — | US | disclosed |
| US-9181233-B2 | Inhibitors of glutaminyl cyclase | PROBIODRUG AG (DE) | 2015-11-10 | — | — | US | disclosed |
| US-8377983-B2 | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors | TRANSTECH PHARMA, INC. (US) | 2013-02-19 | — | — | US | disclosed |
| EP-2542549-A2 | INHIBITORS OF GLUTAMINYL CYCLASE | Probiodrug AG (DE) | 2013-01-09 | — | — | EP | disclosed |
| US-20110224259-A1 | NOVEL INHIBITORS | PROBIODRUG AG (DE) | 2011-09-15 | — | — | US | disclosed |
| US-20110224259-A1 | NOVEL INHIBITORS | PROBIODRUG AG (DE) | 2011-09-15 | — | — | US | disclosed |
| WO-2011107530-A2 | NOVEL INHIBITORS | PROBIODRUG AG (DE) | 2011-09-09 | — | — | WO | disclosed |
| US-7820821-B2 | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors | TRANSTECH PHARMA, INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-20100152170-A1 | Benzazole Derivatives, Compositions, And Methods Of Use As Aurora Kinase Inhibitors | TRANSTECH PHARMA, INC. (US) | 2010-06-17 | — | — | US | disclosed |
| EP-1987028-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS | Transtech Pharma, Inc. (US) | 2008-11-05 | — | — | EP | disclosed |
| US-20070219235-A1 | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors | VTVX HOLDINGS I LLC | 2007-09-20 | — | — | US | disclosed |
| WO-2007095124-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2007-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10961202-B2 | Bis-benzimidazole compounds and methods of using the same | HNRNPH1, HNRNPH3, HNRNPUL2 | TSHR 3601/4885MAPT 60/4885TDP1 79/4885 |
| US-20110224259-A1 | NOVEL INHIBITORS | QPCT, GLUL, GLS | TSHR 3747/4885MAPT 4009/4885TDP1 1299/4885 |
| US-20190152924-A1 | BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING THE SAME | HNRNPH1, HNRNPH3, HNRNPUL2 | TSHR 3601/4885MAPT 60/4885TDP1 79/4885 |
| US-20160031855-A1 | PROTEIN KINASE INHIBITORS | FGFR1, FGFR2, FGFR3 | TSHR 1569/4885MAPT 3430/4885TDP1 2417/4885 |
| US-20100152170-A1 | Benzazole Derivatives, Compositions, And Methods Of Use As Aurora Kinase Inhibitors | AURKC, AURKA, AURKB | TSHR 4683/4885MAPT 1464/4885TDP1 871/4885 |
| US-20070219235-A1 | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors | AURKC, AURKA, AURKB | TSHR 4683/4885MAPT 1464/4885TDP1 871/4885 |
| US-20170114275-A1 | PHOSPHORESCENT TRANSITION METAL COMPLEX, ITS PREPARATION AND USE | DNAJA3, HSPE1, MDH2 | TSHR 3090/4885MAPT 2989/4885TDP1 2894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.