Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7026655 | 0.80 | CHRM2 (0.40) | ALDH1A1LMNATSHRMEN1KMT2A | |
| SCHEMBL6298780 | 0.78 | — | — | |
| SCHEMBL10808304 | 0.76 | EGLN1 (0.35) | ALDH1A1LMNA | |
| SCHEMBL11496159 | 0.75 | ALOX15 (0.31) | — | |
| SCHEMBL7347262 | 0.75 | — | — | |
| SCHEMBL5033844 | 0.75 | HDAC6 (0.37) | MEN1KMT2A | |
| SCHEMBL14817327 | 0.75 | ALDH1A1 (0.41) | ALDH1A1KMT2A | |
| SCHEMBL5759921 | 0.74 | NPC1 (0.35) | ALDH1A1LMNATSHRMEN1KMT2A | |
| SCHEMBL11594609 | 0.73 | TDP1 (0.41) | ALDH1A1FFAR3 | |
| SCHEMBL3422429 | 0.73 | DGAT1 (0.39) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1587818-A2 | 17-CARBAMOYLOXY CORTISOL DERIVATIVES AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2005-10-26 | — | — | EP | claimed |
| WO-2004066920-A2 | 17-CARBAMOYLOXY CORTISOL DERIVATIVES AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | MERCK & CO. INC. (US) | 2004-08-12 | — | — | WO | claimed |
| EP-1587818-A2 | 17-CARBAMOYLOXY CORTISOL DERIVATIVES AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004066920-A2 | 17-CARBAMOYLOXY CORTISOL DERIVATIVES AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | MERCK & CO. INC. (US) | 2004-08-12 | — | — | WO | disclosed |