Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 3/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.35 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980610 | 0.80 | TRPA1 (0.43) | CYP19A1 | |
| SCHEMBL28028823 | 0.74 | CACNA2D1 (0.44) | CYP19A1KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL9670114 | 0.72 | MAPK14 (0.49) | PTGDR2 | |
| SCHEMBL4098293 | 0.70 | LOXL2 (0.49) | PTGDR2LOXL2KDM4EKCNH3 | |
| SCHEMBL14837325 | 0.70 | ROCK1 (0.45) | CYP19A1 | |
| SCHEMBL6189088 | 0.70 | PTGDR2 (0.36) | PTGDR2LOXL2KDM5AKDM4CKDM5B | |
| SCHEMBL27695771 | 0.70 | NR3C2 (0.42) | PTGDR2LOXL2KCNH3 | |
| SCHEMBL5146094 | 0.69 | CTSA (0.51) | CTSAMEN1ALDH1A1PKMKMT2A | |
| SCHEMBL6954666 | 0.69 | F2RL1 (0.43) | — | |
| SCHEMBL3133992 | 0.69 | LOXL2 (0.36) | PTGDR2LOXL2KDM4ECTSAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105814-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2005-11-10 | — | — | WO | disclosed |