Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL8084688 | 0.90 | — | — | |
| Tyrosine SCHEMBL6511987 | 0.88 | SLC7A5 (0.36) | SLC7A5F2 | |
| Proline SCHEMBL7630910 | 0.85 | ITGB3 (0.31) | ITGB3ITGA2BSLC7A5 | |
| Tyrosine SCHEMBL7630915 | 0.83 | SLC7A5 (0.39) | SLC7A5 | |
| Histidine SCHEMBL5058220 | 0.80 | ALOX15 (0.38) | SLC7A5 | |
| Tyrosine SCHEMBL6157198 | 0.79 | SLC7A5 (0.35) | SLC7A5 | |
| Tyrosine SCHEMBL4948067 | 0.79 | SLC7A5 (0.35) | SLC7A5 | |
| Histidine SCHEMBL27576520 | 0.79 | — | — | |
| Tyrosine SCHEMBL8185595 | 0.78 | F2 (0.35) | F2 | |
| Histidine SCHEMBL5583260 | 0.78 | CYP3A4 (0.31) | SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050095673-A1 | Methods for production of growth-promoting proteins and peptides for kidney epithelial cells | CHICAGO, THE UNIVERSITY OF | 2005-05-05 | — | — | US | claimed |
| US-20030176340-A1 | Methods for production of growth-promoting proteins and peptides for kidney epithelial cells | ARCH DEVELOPMENT CORPORATION | 2003-09-18 | — | — | US | claimed |