Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL6511983 | 0.90 | ITGB3 (0.32) | — | |
| Tyrosine SCHEMBL6511987 | 0.88 | SLC7A5 (0.36) | — | |
| Proline SCHEMBL7630910 | 0.86 | ITGB3 (0.31) | — | |
| Histidine SCHEMBL6554680 | 0.85 | — | — | |
| Histidine SCHEMBL27576520 | 0.84 | — | — | |
| Tyrosine SCHEMBL6554731 | 0.84 | SLC7A5 (0.36) | — | |
| Histidine SCHEMBL27501345 | 0.84 | ALOX15 (0.30) | — | |
| Tyrosine SCHEMBL7630915 | 0.84 | SLC7A5 (0.39) | — | |
| Tyrosine SCHEMBL6554735 | 0.83 | SLC7A5 (0.39) | — | |
| Tyrosine SCHEMBL6554685 | 0.81 | ITGA4 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1034187-A1 | $i(IN VITRO) AND $i(IN VIVO) GROWTH-PROMOTING PROTEINS AND PEPTIDES FOR KIDNEY EPITHELIAL CELLS | ARCH DEVELOPMENT CORPORATION (US) | 2000-09-13 | — | — | EP | claimed |
| WO-1999026974-A1 | IN VITRO AND IN VIVO GROWTH-PROMOTING PROTEINS AND PEPTIDES FOR KIDNEY EPITHELIAL CELLS | ARCH DEVELOPMENT CORPORATION (US) | 1999-06-03 | — | — | WO | claimed |