Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.37 |
| ▸ | IKBKB | O14920 | 6/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6506816 | 0.87 | CHEK1 (0.36) | IKBKBCHEK1KDM4EALDH1A1MAPT | |
| SCHEMBL6506529 | 0.81 | KDM5A (0.36) | KDM5AIKBKBJAK2JAK3CHEK1 | |
| SCHEMBL6512268 | 0.81 | IKBKB (0.35) | KDM5AIKBKBJAK2JAK3CHEK1 | |
| SCHEMBL6505649 | 0.77 | IKBKB (0.45) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL6508772 | 0.76 | IKBKB (0.38) | IKBKBJAK2JAK3CHEK1MAP4K4 | |
| SCHEMBL6505865 | 0.73 | IKBKB (0.58) | IKBKBJAK2JAK3CHEK1MAP4K4 | |
| SCHEMBL6509499 | 0.69 | PTK2 (0.40) | KDM5AMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL6512326 | 0.68 | IKBKB (0.36) | KDM5AIKBKBJAK2JAK3CHEK1 | |
| SCHEMBL6507152 | 0.62 | IKBKB (0.57) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL6508526 | 0.62 | PTK2 (0.40) | MEN1KMT2AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |