SCHEMBL6512592

SCHEMBL6512592

C#Cc1ccc(-c2ccc(C#C)cc2[N+](=O)[O-])c(N)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.40
TDP1 Q9NUW8 4/20 0.40
TSHR P16473 3/20 0.40
ALDH1A1 P00352 3/20 0.40
CYP3A4 P08684 2/20 0.40
ALOX15 P16050 2/20 0.40
MEN1 O00255 1/20 0.40
POLB P06746 1/20 0.40
KMT2A Q03164 1/20 0.40
VCAM1 P19320 2/20 0.38
LMNA P02545 3/20 0.36
P2RY6 Q15077 1/20 0.35
RECQL P46063 1/20 0.34
MAPK1 P28482 1/20 0.34
HSD17B10 Q99714 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
PTPN11 Q06124 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2394881 0.83 MAPT (0.58) MAPTTDP1TSHRALDH1A1CYP3A4
SCHEMBL2186163 0.78 TDP1 (0.41) MAPTTDP1TSHRALDH1A1CYP3A4
SCHEMBL6511117 0.78 CYP1A2 (0.39) MAPTTDP1TSHRALDH1A1CYP3A4
SCHEMBL11689602 0.77 TSHR (0.50) MAPTTDP1TSHRALDH1A1CYP3A4
SCHEMBL9793498 0.74 PTPN11 (0.49) MAPTTDP1TSHRALDH1A1CYP3A4
SCHEMBL6516643 0.73 TDP1 (0.42) MAPTTDP1TSHRALDH1A1CYP3A4
SCHEMBL5068701 0.73 MAPT (0.33) MAPTTDP1TSHRALDH1A1CYP3A4
SCHEMBL2372334 0.73 ALDH1A1 (0.56) MAPTTDP1ALDH1A1MEN1KMT2A
SCHEMBL2683998 0.73 VCAM1 (0.69) TDP1TSHRVCAM1MAPK1
SCHEMBL11377708 0.73 MAPK1 (0.56) MAPTTSHRALDH1A1CYP3A4ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050101063-A1 Three-terminal field-controlled molecular devices TOUR JAMES M (US) 2005-05-12 US disclosed
WO-2002035580-A2 THREE-TERMINAL FIELD-CONTROLLED MOLECULAR DEVICES MOLECULAR ELECTRONICS CORPORATION (US) 2002-05-02 WO disclosed