Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27799226 | 0.83 | MAPT (0.60) | MAPTTDP1MEN1KMT2APOLB | |
| SCHEMBL6512592 | 0.83 | MAPT (0.40) | MAPTTDP1MEN1KMT2APOLB | |
| SCHEMBL11689602 | 0.82 | TSHR (0.50) | MAPTTDP1ALDH1A1CYP3A4TSHR | |
| SCHEMBL203082 | 0.81 | VCAM1 (0.64) | MAPTTDP1MEN1KMT2APOLB | |
| SCHEMBL9793498 | 0.79 | PTPN11 (0.49) | MAPTTDP1MEN1KMT2APOLB | |
| SCHEMBL11377708 | 0.78 | MAPK1 (0.56) | MAPTMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL2372334 | 0.78 | ALDH1A1 (0.56) | MAPTTDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL2683998 | 0.78 | VCAM1 (0.69) | TDP1TSHRVCAM1 | |
| SCHEMBL9356251 | 0.77 | CASP3 (0.54) | MAPTTDP1MEN1KMT2APOLB | |
| SCHEMBL29319281 | 0.75 | ALDH1A1 (0.44) | MAPTTDP1KMT2AALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10961202-B2 | Bis-benzimidazole compounds and methods of using the same | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-03-30 | — | — | US | disclosed |
| CN-106977549-B | Phosphorescent transition metal complexes, their preparation and use | 香港城市大学 | 2021-03-30 | — | — | CN | disclosed |
| EP-3710442-A2 | BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING THE SAME | The Scripps Research Institute (US) | 2020-09-23 | — | — | EP | disclosed |
| US-20190152924-A1 | BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING THE SAME | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2019-05-23 | — | — | US | disclosed |
| US-9890327-B2 | Phosphorescent transition metal complex, its preparation and use | CITY UNIVERSITY OF HONG KONG (HK) | 2018-02-13 | — | — | US | disclosed |
| US-9890327-B2 | Phosphorescent transition metal complex, its preparation and use | CITY UNIVERSITY OF HONG KONG (HK) | 2018-02-13 | — | — | US | disclosed |
| EP-2981533-B1 | PROTEIN KINASE INHIBITORS | ORION CORP (FI) | 2017-12-06 | — | — | EP | disclosed |
| CN-106977549-A | Phosphorescent transition metal complexes, their preparation and use | 香港城市大学 | 2017-07-25 | — | — | CN | disclosed |
| US-20170114275-A1 | PHOSPHORESCENT TRANSITION METAL COMPLEX, ITS PREPARATION AND USE | CITY UNIVERSITY OF HONG KONG (HK) | 2017-04-27 | — | — | US | disclosed |
| US-20170114275-A1 | PHOSPHORESCENT TRANSITION METAL COMPLEX, ITS PREPARATION AND USE | CITY UNIVERSITY OF HONG KONG (HK) | 2017-04-27 | — | — | US | disclosed |
| US-20110224259-A1 | NOVEL INHIBITORS | PROBIODRUG AG (DE) | 2011-09-15 | — | — | US | disclosed |
| US-20110224259-A1 | NOVEL INHIBITORS | PROBIODRUG AG (DE) | 2011-09-15 | — | — | US | disclosed |
| WO-2011107530-A2 | NOVEL INHIBITORS | PROBIODRUG AG (DE) | 2011-09-09 | — | — | WO | disclosed |
| WO-2011107530-A2 | NOVEL INHIBITORS | PROBIODRUG AG (DE) | 2011-09-09 | — | — | WO | disclosed |
| US-7820821-B2 | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors | TRANSTECH PHARMA, INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-20100152170-A1 | Benzazole Derivatives, Compositions, And Methods Of Use As Aurora Kinase Inhibitors | TRANSTECH PHARMA, INC. (US) | 2010-06-17 | — | — | US | disclosed |
| CN-101379060-A | Benzoxazole-based derivatives as Aurora kinase inhibitors, compositions, and methods of use | TRANSTECH PHARMA INC (US) | 2009-03-04 | — | — | CN | disclosed |
| EP-1987028-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS | Transtech Pharma, Inc. (US) | 2008-11-05 | — | — | EP | disclosed |
| US-20070219235-A1 | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors | VTVX HOLDINGS I LLC | 2007-09-20 | — | — | US | disclosed |
| WO-2007095124-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2007-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10961202-B2 | Bis-benzimidazole compounds and methods of using the same | HNRNPH1, HNRNPH3, HNRNPUL2 | MAPT 60/4885TDP1 79/4885MEN1 1360/4885 |
| US-20110224259-A1 | NOVEL INHIBITORS | QPCT, GLUL, GLS | MAPT 4009/4885TDP1 1299/4885MEN1 2453/4885 |
| US-20190152924-A1 | BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING THE SAME | HNRNPH1, HNRNPH3, HNRNPUL2 | MAPT 60/4885TDP1 79/4885MEN1 1360/4885 |
| US-20100152170-A1 | Benzazole Derivatives, Compositions, And Methods Of Use As Aurora Kinase Inhibitors | AURKC, AURKA, AURKB | MAPT 1464/4885TDP1 871/4885MEN1 895/4885 |
| US-20070219235-A1 | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors | AURKC, AURKA, AURKB | MAPT 1464/4885TDP1 871/4885MEN1 895/4885 |
| US-20170114275-A1 | PHOSPHORESCENT TRANSITION METAL COMPLEX, ITS PREPARATION AND USE | DNAJA3, HSPE1, MDH2 | MAPT 2989/4885TDP1 2894/4885MEN1 1902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.