Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2426169 | 0.85 | ALDH1A1 (0.60) | ALDH1A1HIF1AVCAM1CA1MMP2 | |
| SCHEMBL697848 | 0.83 | ALDH1A1 (0.58) | ALDH1A1HIF1AVCAM1CA1MMP2 | |
| SCHEMBL11689602 | 0.82 | TSHR (0.50) | ALDH1A1HIF1AVCAM1CA1CA14 | |
| SCHEMBL16958110 | 0.81 | ALDH1A1 (0.56) | ALDH1A1HIF1AVCAM1CA1MMP2 | |
| SCHEMBL352298 | 0.81 | VCAM1 (0.64) | ALDH1A1HIF1AVCAM1CA1MMP2 | |
| SCHEMBL9793498 | 0.79 | PTPN11 (0.49) | ALDH1A1VCAM1CA1CA14TDP1 | |
| SCHEMBL11377708 | 0.78 | MAPK1 (0.56) | ALDH1A1HIF1AVCAM1CA1LMNA | |
| SCHEMBL2394881 | 0.78 | MAPT (0.58) | ALDH1A1VCAM1TDP1LMNAMAPT | |
| SCHEMBL2683998 | 0.78 | VCAM1 (0.69) | VCAM1TDP1 | |
| SCHEMBL9937018 | 0.75 | VCAM1 (0.60) | ALDH1A1VCAM1TDP1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547665-B1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2018-07-04 | — | — | EP | disclosed |
| EP-2547665-B1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2018-07-04 | — | — | EP | disclosed |
| US-20170027173-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, LLC (US) | 2017-02-02 | — | — | US | disclosed |
| US-20170027173-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, LLC (US) | 2017-02-02 | — | — | US | disclosed |
| US-9499524-B2 | Insecticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2016-11-22 | — | — | US | disclosed |
| US-9499524-B2 | Insecticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2016-11-22 | — | — | US | disclosed |
| US-20160302414-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2016-10-20 | — | — | US | disclosed |
| US-20160302414-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2016-10-20 | — | — | US | disclosed |
| US-9249138-B2 | Anti-viral compounds | ABBVIE INC. (US) | 2016-02-02 | — | — | US | disclosed |
| US-20140213595-A1 | ANTI-VIRAL COMPOUNDS | ABBVIE INC. (US) | 2014-07-31 | — | — | US | disclosed |
| US-8546405-B2 | Anti-viral compounds | ABBOTT LABORATORIES (US) | 2013-10-01 | — | — | US | disclosed |
| EP-2547665-A1 | INSECTICIDAL COMPOUNDS | Syngenta Participations AG (CH) | 2013-01-23 | — | — | EP | disclosed |
| US-20130012547-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2013-01-10 | — | — | US | disclosed |
| US-20130012547-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2013-01-10 | — | — | US | disclosed |
| EP-2367823-A1 | ANTI-VIRAL COMPOUNDS | Abbott Laboratories (US) | 2011-09-28 | — | — | EP | disclosed |
| WO-2011113756-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011113756-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2011-09-22 | — | — | WO | disclosed |
| WO-2010075380-A1 | ANTI-VIRAL COMPOUNDS | ABBOTT LABORATORIES (US) | 2010-07-01 | — | — | WO | disclosed |
| US-20100160355-A1 | Anti-Viral Compounds | ABBOTT LABORATORIES (US) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140213595-A1 | ANTI-VIRAL COMPOUNDS | HAVCR2, EIF2AK2, MAVS | ALDH1A1 2858/4885HIF1A 1619/4885VCAM1 931/4885 |
| US-20170027173-A1 | INSECTICIDAL COMPOUNDS | ACHE, AADAC, CASP3 | ALDH1A1 391/4885HIF1A 4690/4885VCAM1 4756/4885 |
| US-20100160355-A1 | Anti-Viral Compounds | HAVCR2, EIF2AK2, MAVS | ALDH1A1 2858/4885HIF1A 1619/4885VCAM1 931/4885 |
| US-20160302414-A1 | INSECTICIDAL COMPOUNDS | ACHE, AADAC, CASP3 | ALDH1A1 391/4885HIF1A 4690/4885VCAM1 4756/4885 |
| US-20130012547-A1 | INSECTICIDAL COMPOUNDS | ACHE, AADAC, CYP51A1 | ALDH1A1 335/4885HIF1A 4668/4885VCAM1 4768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.