Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12268231 | 0.80 | RIPK1 (0.46) | ALDH1A1CYP3A4CYP2C9CYP2C19RIPK1 | |
| SCHEMBL3270164 | 0.78 | PPARA (0.55) | ALDH1A1CYP3A4CYP2C9CYP2C19RIPK1 | |
| SCHEMBL6511088 | 0.77 | ALDH1A1 (0.35) | ALDH1A1 | |
| SCHEMBL3270827 | 0.77 | MMP8 (0.53) | ALDH1A1CYP3A4CYP2C9CYP2C19RIPK1 | |
| SCHEMBL12268256 | 0.76 | RIPK1 (0.42) | ALDH1A1CYP3A4CYP2C9CYP2C19RIPK1 | |
| SCHEMBL29290738 | 0.75 | SMN1; SMN2 (0.48) | ALDH1A1CYP3A4CYP2C9CYP2C19RIPK1 | |
| SCHEMBL16321815 | 0.72 | RIPK1 (0.53) | ALDH1A1CYP3A4CYP2C9CYP2C19RIPK1 | |
| SCHEMBL27446496 | 0.72 | SMN1; SMN2 (0.48) | ALDH1A1CYP3A4CYP2C9CYP2C19RECQL | |
| SCHEMBL17300282 | 0.72 | RIPK1 (0.50) | ALDH1A1CYP3A4CYP2C9CYP2C19RIPK1 | |
| SCHEMBL27908890 | 0.72 | SMN1; SMN2 (0.57) | ALDH1A1CYP3A4CYP2C9CYP2C19RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227933-A1 | Treatment of bacterial induced diseases using DNA methyl transferase inhibitors | BENKOVIC STEPHEN J | 2005-10-13 | — | — | US | disclosed |
| US-20040259833-A1 | DNA methyl transferase inhibitors | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2004-12-23 | — | — | US | disclosed |
| EP-1420021-A1 | DNA Methyltransferase inhibitors | The Penn State Research Foundation (US) | 2004-05-19 | — | — | EP | disclosed |
| EP-1181291-A2 | DNA METHYLTRANSFERASE INHIBITORS | THE PENN STATE RESEARCH FOUNDATION (US) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000075142-A2 | DNA METHYLTRANSFERASE INHIBITORS | THE PENN STATE RESEARCH FOUNDATION (US) | 2000-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227933-A1 | Treatment of bacterial induced diseases using DNA methyl transferase inhibitors | DNMT1, TPMT, GNMT | ALDH1A1 2015/4885CYP3A4 4010/4885CYP2C9 4623/4885 |
| US-20040259833-A1 | DNA methyl transferase inhibitors | DNMT1, DNMT3A, DIMT1 | ALDH1A1 2274/4885CYP3A4 2243/4885CYP2C9 2726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.