Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | NPR3 | P17342 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6531904 | 1.00 | HPGD (0.46) | HPGDSMN1; SMN2L3MBTL1LMNAMAPT | |
| SCHEMBL6532622 | 0.78 | KCNH3 (0.51) | HPGDSMN1; SMN2LMNAMAPTCYP2C9 | |
| SCHEMBL6532631 | 0.78 | KCNH3 (0.51) | HPGDSMN1; SMN2LMNAMAPTCYP2C9 | |
| SCHEMBL6530303 | 0.78 | VNN1 (0.44) | L3MBTL1LMNAMAPTCYP2C9NPR3 | |
| SCHEMBL6529952 | 0.78 | NPR3 (0.42) | SMN1; SMN2MAPTCYP2C9NPR3CYP2C19 | |
| SCHEMBL6529959 | 0.78 | NPR3 (0.42) | SMN1; SMN2MAPTCYP2C9NPR3CYP2C19 | |
| SCHEMBL6529224 | 0.76 | NPR3 (0.56) | SMN1; SMN2MAPTCYP2C9NPR3CYP2C19 | |
| SCHEMBL6528199 | 0.74 | ANPEP (0.43) | MAPTCYP2C9NPR3CYP2C19KCNH3 | |
| SCHEMBL6528195 | 0.74 | ANPEP (0.43) | MAPTCYP2C9NPR3CYP2C19KCNH3 | |
| SCHEMBL6529615 | 0.70 | TAS1R3 (0.39) | SMN1; SMN2MAPTCYP2C9NPR3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | claimed |
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |