Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.49 |
| ▸ | HPGD | P15428 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5539635 | 0.80 | ALDH1A1 (0.56) | ALDH1A1TDP1NPC1RAB9AMAPK1 | |
| SCHEMBL6677387 | 0.78 | HPGD (0.35) | ALDH1A1HPGDMAPTNPSR1TDP1 | |
| SCHEMBL9770471 | 0.77 | TDP1 (0.53) | ALDH1A1HPGDMAPTNPSR1TDP1 | |
| SCHEMBL6841221 | 0.77 | HRH3 (0.43) | DRD2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL5168911 | 0.76 | NPC1 (0.65) | ALDH1A1HPGDMAPTTDP1NPC1 | |
| SCHEMBL7514361 | 0.76 | ALDH1A1 (0.49) | ALDH1A1HPGDMAPTNPSR1TDP1 | |
| SCHEMBL12203984 | 0.75 | KDM4E (0.53) | ALDH1A1HPGDMAPTNPSR1TDP1 | |
| SCHEMBL15527792 | 0.75 | MAPT (0.51) | ALDH1A1MAPTTDP1MAPK1KDM4E | |
| SCHEMBL24572066 | 0.73 | ALDH1A1 (0.46) | ALDH1A1HPGDMAPTNPSR1TDP1 | |
| SCHEMBL1607269 | 0.73 | ALDH1A1 (0.54) | ALDH1A1HPGDMAPTNPSR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050118605-A9 | Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation | ISIS PHARMACEUTICALS, INC. | 2005-06-02 | — | — | US | disclosed |
| US-20050037370-A1 | Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation | BAKER BRENDA F (US) | 2005-02-17 | — | — | US | disclosed |
| US-20050032069-A1 | Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation | ISIS PHARMACEUTICALS, INC. | 2005-02-10 | — | — | US | disclosed |
| WO-2004044245-A1 | OLIGOMERIC COMPOUNDS HAVING MODIFIED BASES FOR BINDING TO ADENINE AND GUANINE AND THEIR USE IN GENE MODULATION | ISIS PHARMACEUTICALS, INC. (US) | 2004-05-27 | — | — | WO | disclosed |
| US-5688760-A | BONE DISORDERS TREATED WITH PARATHYROID HORMONE RELATED PROTEINS OR ADENYLATE CYCLASE STIMULATING FACTOR | GENENTECH, INC. (US) | 1997-11-18 | — | — | US | disclosed |
| US-5552540-A | NONRADIOACTIVE LABELS | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 1996-09-03 | — | — | US | disclosed |
| EP-0366685-B1 | NUCLEOSIDE DERIVATIVES | FLOREY HOWARD INST (AU) | 1994-10-19 | — | — | EP | disclosed |
| EP-0561877-A1 | COMPOUNDS AND COMPOSITIONS WHICH INHIBIT BONE RESORPTION | THE UNIVERSITY OF MELBOURNE (AU) | 1993-09-29 | — | — | EP | disclosed |
| WO-1992010511-A1 | COMPOUNDS AND COMPOSITIONS WHICH INHIBIT BONE RESORPTION | THE UNIVERSITY OF MELBOURNE (AU) | 1992-06-25 | — | — | WO | disclosed |
| EP-0366685-A4 | NUCLEOSIDE DERIVATIVES | — | 1991-03-20 | — | — | EP | disclosed |
| EP-0008072-B1 | SUBSTITUTED ANTHRANILIC ACID AMIDES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PREPARATION | CIBA-GEIGY AG (CH) | 1984-02-22 | — | — | EP | disclosed |
| US-4427581-A | BACTERICIDES, FUNGICIDES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-01-24 | — | — | US | disclosed |
| US-4354966-A | Peptides, process for preparation thereof and use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-10-19 | — | — | US | disclosed |
| EP-0057412-A1 | Peptide, process for preparation thereof and use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-08-11 | — | — | EP | disclosed |
| US-4311640-A | ANTIBIOTIC | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-01-19 | — | — | US | disclosed |
| US-4297358-A | AS ANTIALLERGENS | CIBA-GEIGY CORPORATION (US) | 1981-10-27 | — | — | US | disclosed |
| EP-0027260-A2 | Peptides, processes for their preparation and pharmaceutical compositions containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-04-22 | — | — | EP | disclosed |
| EP-0025842-A2 | Peptides, process for their preparation, their pharmaceutical compositions and their intermediates | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-04-01 | — | — | EP | disclosed |
| EP-0013666-A1 | Phenanthroline derivatives, process for their preparation and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1980-07-23 | — | — | EP | disclosed |
| EP-0008072-A1 | Substituted anthranilic acid amides, process for their preparation, pharmaceutical compositions containing them and their preparation | CIBA-GEIGY AG (CH) | 1980-02-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050037370-A1 | Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation | RNMT, RRBP1, G3BP1 | ALDH1A1 4679/4885HPGD 4184/4885MAPT 4053/4885 |
| US-20050118605-A9 | Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation | RNMT, RRBP1, G3BP1 | ALDH1A1 4679/4885HPGD 4184/4885MAPT 4053/4885 |
| US-20050032069-A1 | Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation | RNMT, RRBP1, G3BP1 | ALDH1A1 4679/4885HPGD 4184/4885MAPT 4053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.